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doi: 10.3389/fnagi.2025.1495769 Received 13 September 2024 Accepted 28 March 2025 Published 09 May 2025 Volume 17 - 2025 Edited by Ramesh Kandimalla, Indian Institute of Chemical Technology (CSIR), India Reviewed by Chunchen Xiang, Capital Medical University, China Bruno piljak, University of Zagreb, Croatia Updates Copyright 2025 Li, Zhang, Yu, Xue and Hu

Vitamin D Studies have shown that iron overload in the pancreas contributes to T2DM pathogeneses

Lactate and lactylation are also associated with the release of high mobility group box protein 1 (HMGB1), a damage-associated molecular pattern (DAMP), from activated macrophages 91,271

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The 3-D cell model was made by culturing cells (2 10 5 1.0 10 6 ) with high glucose DMEM supplemented with 30% bovine collagen solution overnight