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Representative UMAPs comparing cryopreserved and fresh biopsies and coarse cell subset annotations, as well as the scRNA-seq DE genes, were generated from the MULTI-seq labeled samples as described above

Melatonin has also reduced pro-angiogenic factor expression, such as VEGF, and subsequently inhibits tumor angiogenesis [94, 112]

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As membrane-localized DPP4 is required for NADPH oxidase-dependent lipid peroxidation, p53 -mediated nuclear sequestration effectively inhibits ferroptosis initiation ( P53 can induce the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21), leading to cell cycle arrest

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However, further studies in long term using large population are needed in order to better understand how GSH-Px contributes to the development of periodontal diseases using knockout and knockdown techniques