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The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients

Besides making a choice between NMN and NR, more precise data about the dosage and more detailed mechanism are needed

Unlike peripheral cells, mature dopaminergic neurons barely express Bcl-2, and their anti-apoptotic capacity relies mainly on Bcl-xL [36]Bcl-xL maintains mitochondrial membrane integrity either by directly binding to Bax to prevent its mitochondrial localization or by inhibiting MOMP formation [37]

209,210 For targeted NADs, including ASO and siRNA, when the relevant genetic information of the disease is determined, lead compounds can be designed for the gene sequence to avoid off-target effects during development