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Description

Accordingly, preferably excluded from the present invention are one or more polynucleotides consisting of a nucleotide sequence described by the general formula of a-b, where a is any integer between 1 to 2640 of SEQ ID NO:1, b is an integer between 15 to 2654, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO:1, and where b is greater than or equal to a+14

Cytidine monophosphate kinase 2 (Cmpk2), a critical mitochondria-associated gene, elevates free mtDNA production under normal conditions, leading to the formation of inflammasome-mediated inflammatory factors