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Nanomaterials 12 (7), 1037

A decrease in the levels of TNF--induced IKK/ (inhibitor of nuclear factor kappa-B kinase subunit beta), IB (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), and NF-B (nuclear factor kappa beta cells) was noted

Thus, this epigenetic alteration is now considered as a cancer biomarker but could as well play a driving role in multistep cancer development, especially well documented in prostate cancer development