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Metformin may be considered for patients with metabolic complications due to its potential to inhibit hypoxia-induced fibrosis in adipose tissue.40 Oral analgesics may be used for pain management, although systematic data on pharmacological therapies are lacking.8 Despite its association with sex hormones, there is no scientific basis for the use of estrogens, progestins, testosterone, or hormonal implants in the treatment of lipedema

There is a need to develop inhaled formulations and selective inhibitors of the - subgroups

It forms the structural framework of the skin, providing firmness, elasticity, and hydration

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Oxidative stress causes neuronal cell death, which contributes to the progressive cognitive decline seen in AD (82)

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