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substituted is intended to mean that one or more hydrogen atoms in the group indicated is replaced with one or more independently selected suitable substituents, provided that the normal valency of each atom to which the substituent/s are attached is not exceeded, and that the substitution results in a stable compound

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Carbon monoxide diffuses across the retina into the venous circulation, traveling through bodily fluids to the brain, where it mitigates neuroinflammation and exerts protective effects (Nowak et al., 2022)

Mooser, 1958)

Moreover, the risk of vitamin B12 deficiency also increases with increased metformin dose and duration of its use

It is a syndrome called the "caregiver placebo effect"