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PDK1 then phosphorylates AKT at the Thr308 site, activating it (84), with mTORC2 also contributing to AKT activation (85)

doi: 10.3390/ijms26020669 13 PrzystalJMHajjiNKhozoieCRenziehausenAZengQAbaituaFet al

Existing research indicates that estrogens may primarily induce a proliferative phenotype in PASMCs by downregulating the expression of bone morphogenetic protein receptor type II, rendering women more susceptible to PAH [104]