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Researchers studied the use of Alimta and cisplatin as a second-line treatment in a phase 3 trial

Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor B (NF-B) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling

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The timing of intervention needs to take the pharmacokinetics (PK) of the therapeutic agent and the targeted cell type into consideration

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