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However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

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Anti-inflammatory and Immunomodulatory Effects (IL-1, IL-6, TNF-) Inflammation is a natural and necessary part of the healing process, but chronic or excessive inflammation can impede tissue repair and contribute to pain and tissue degradation

Because a large number of comparisons were performed on the relative abundance data, main effect results from these analyses also underwent a BenjaminiHochberg false discovery rate (FDR) correction for multiple comparisons, and instances where a result was significant after this correction have been duly noted

For example, chronic stomach inflammation and autoimmune activity can interfere with the digestive system, reducing the bodys ability to absorb B12

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