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Ancel, S., Stuelsatz, P

Nutrients , 11 , 1104

(2) Lipid peroxidation, a key driver of ferroptosis, is counteracted by acyl-CoA synthetase long-chain family member 4 (ACSL4) downregulation, arachidonate lipoxygenases (ALOXs) activation, and glutathione peroxidase-4 (GPX4)-dependent lipid peroxide detoxification, allowing tumor cells to escape ferroptotic cell death [8]