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In 2010, a study from the Singapore General hospital, using Connectivity Map (CMap) from the Broad Institute in Boston to obtain gene expression data, searched for molecular treatments for aggressive metastatic colon cancer

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In addition, somatic symptoms were mild in these patients

DOI: 10.1023/A:1025493705728 Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA

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The effective contact time with the sublingual membrane is shorter, which can reduce total absorption despite the faster initial dissolution