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This study also found that SIRPG knockout in Jurkat T cells resulted in fewer T cell conjugates, which suggests a role in T cell to T cell interactions (83)

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Table 2 Drugs in clinical trials of fragile X syndrome

These modifications form a self-reinforcing regulatory cycle: phosphorylation activates E3 ligases, while ubiquitination reciprocally regulates kinase signaling, ultimately shaping context-dependent therapeutic responses (Fig

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