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A previous study using the BigBlue lacZ reporter system, showed that Polk-/- mice exhibit a spontaneous mutator phenotype 31 , but these findings were limited to the small reporter assay and do not fully reflect the complexity of the genome-wide mutational processes occurring in tissues

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These enzymatic reactions profoundly influence energy homeostasis, repair capacity, cellular stress resistance, and gene expression Biological Activity NAD + is indispensable for over 400 cellular reactions, supports mitochondrial function, and modulates antioxidant defenses

Nat Rev Endocrinol 12 , 299308 (2016)

In some embodiments, the compositions comprise from about 0.01 milligrams (mg) to about 10 mg of cannabinoid and about 0.5 mg to about 50 mg cofactor or precursor thereof per milliliter of composition

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