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Overexpression of P-gp in cancerous cells is a principal factor contributing to MDR against anti-cancer drugs like doxorubicin (DOX), etoposide, olaparib, paclitaxel, and vinblastine, amongst others [35, 39,40,41,42,43]

TC, GH, ES and DW edited and drafted the manuscript

Interestingly, we noticed that non-acral melanomas also show amplification of TERT , contrary to what has been traditionally accepted

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The doses of silymarin and NSO were administered daily by gavage, whereas NSS was crushed to a fine powder and mixed with the diet at a dose of 2.5 g/kg (calculated to correspond to 250 mg/kg body weight)

Roth 401(k) and traditional 401(k) plans have an aggregate contribution limit for employee deferrals of $23,000 in 2024