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1-Methyl-5-Aminoquinolinium

The peptide has never cleared a Phase III clinical trial, no sponsor has filed a New Drug Application, and FDA has never issued an approval letter for any formulation of AOD-9604 for any condition

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PMID: 20445536

alkylation of a C3-amino-quinoline derived precursor, such as compound 8 may be achieved via reductive amination with, for example, triethyl orthoformate in TFA followed by treatment with NaBH 4 to give the corresponding secondary C3-amine derivative (such as N-methyl-C3-amino-quinoline 9)

Community protocols describe a 50 mg/day starting phase lasting 1-2 weeks, escalating to 100-150 mg/day based on tolerance