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Overdoses of vitamin B12 are rare since it has a low toxicity level as a water-soluble vitamin excreted through the urine

7.3 Terpenoids: Nrf2 activators and inflammation resolvers Terpenoids combat ALD by activating the Nrf2 pathway to transcriptionally upregulate antioxidant genes such as HO-1 and SOD-1, thereby restoring redox balance (Zhao et al., 2019)

Suspension culture and differentiation into liver organoids For differentiation of hPSCs into organoids, cells were harvested by incubation with Accutase (Life Technologies) for 10 min at 37 C until the cells had detached

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These combined strategies use proven therapies like TENS and PEMF along with new methods to give patients better long-term results and quality of life (Wang et al., 2024)

6.1 Comprehensive strategies to overcome translational challenges The clinical translation of SFN faces significant pharmacological hurdles that require a multidisciplinary approach