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This formulation employs Chiasma Pharmas Transient Permeation Enhancer (TPE) technology, which temporarily and reversibly modulates TJs, particularly by redistributing TJ proteins such as ZO-1 and claudins (Tuvia et al., 2014)

^ Grill D, Tausz T, De Kok LJ (2001)

Dayer R, Fischer BB, Eggen RI, Lemaire SD (2008) The peroxiredoxin and glutathione peroxidase families in Chlamydomonas reinhardtii

Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses

Ketogenic treatment reduces the percentage of a LHON heteroplasmic mutation and increases mtDNA amount of a LHON homoplasmic mutation