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These cells contribute to the fibrotic response by activating resident fibroblasts and immune cells through the persistent induction of the TGF-/Smad, Wnt/-catenin, and Hedgehog signaling, which collectively drive myofibroblast differentiation and excessive extracellular matrix deposition

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Nature 490 , 543 (2012)

Modifications can be introduced into an antibody of the disclosure by standard techniques known in the art, such as site-directed mutagenesis and PCR-mediated mutagenesis