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Despite the inherent challenges of predicting clinical phenotypes in diploid humans, our patient CBS activity scores, derived from variants that had been individually assessed in a haploid yeast model, correlated significantly with age of disease onset and with disease severity

Ge Y-X, Zhang T-W, Zhou L, et al

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Authorship X.F.H., A.L., and H.M.C

Increased necrosis was observed amongst the untreated granulomas (Figure 2M)