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Acetaminophen Injection - Clinical Pharmacology 12.1 Acetaminophen Injection Mechanism of Action The precise mechanism of the analgesic and antipyretic properties of acetaminophen is not established but is thought to primarily involve central actions

This inhibition causes AICAR to accumulate intracellularly

Moreover, a significant fraction of subjects, commonly referred to as treatment-resistant, do not respond to these antidepressants despite the use of various therapeutic strategies (173)