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mTORC1 further supports glycine synthesis by enhancing glycolytic flux and glucose uptake, contributing to a self-reinforcing cycle that sustains collagen production [108, 109]

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However, phenobarbital and TCDD are also phase II enzyme inducers with induction of some glutathione transferases and UDP-glucuronyltransferases in centrilobular hepatocytes and predominant periportal expression of glutathione peroxidase (Lindros 1997)

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