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Upon immediate ascent to altitude, there is a very rapid hyperventilatory response to hypoxia to raise PO 2 , which leads to respiratory alkalosis, resulting in decreased H + , increased pH and increased renal HCO 3 excretion, resulting in decreased blood HCO 3

This down-regulation implies a reduced capacity to inhibit pain signals, potentially exacerbating chronic pain experiences in IBS patients

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Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein

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