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More importantly, activation of TGF- in the right place at the right time is necessary to recruit stem/progenitor cells to participate in the tissue regeneration/remodeling process, whereas sustained abnormalities in TGF- ligand expression, bioavailability, activation, receptor assemblage/stabilization, or post-transcriptional modifications will inevitably disrupt the normal physiology, and lead to pathobiology of major diseases either through the recruitment of excessive progenitors (as seen in osteoarthritis or CamuratiEngelmann disease), or trans-differentiation of resident cells to unfavorable lineage commitment (as seen in epithelial to mesenchymal transition during cancer metastasis or tissue/organ fibrosis)

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This benefit is a result of the fact that glutathione supports the production of collagen

Fraser et al., 2002)

Both the flowers and leaves are promising remedies for arthritis, allergies, and gastrointestinal inflammation [14]

On the other hand, the immunohistochemical assessment showed that the GFAP immunoreactive-positive substances were observed in the astrocytes cell bodies and processes