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To summarise, normally occurring reactive astrogliosis is in the first instance an intrinsic and evolutionary conserved set of diverse astrocyte responses that are aimed at neuroprotection, maintenance of tissue homoeostasis and preservation of nervous tissue integrity

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Dis Markers 2006, 22(1):8393

Much like depression, brain fog is often a result of oxidative stress or inflammation occurring in the brain

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In this sense, a recent study using scRNA-seq approaches with astrocyte-specific Ribotag RNA profiling and bioinformatics analysis identified a subpopulation of reactive astrocytes expressing the GM-CSFMAFG pathway in the EAE model and in MS (130)