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Curr Top Behav Neurosci

SIRT3, SIRT4, and SIRT5 are mitochondrial and can shuttle to the nucleus ( The enzymatic activity of SIRTs is dependent on NAD + as a cofactor and plays an important role in controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis

These variations imply potential modulatory actions on stress responses, possibly through interactions with opioidergic systems and broader endocrine signaling pathways

What Does the Research Actually Show

Mammalian sirtuins: biological insights and disease relevance

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