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It is not an allergy or an autoimmune response to histamine (even if it sounds like it)

Other causes of B12 deficiency include pernicious anemia, an uncommon (and spookily named) autoimmune disease that destroys parietal stomach cells

1 Introduction Intestine, one part of the digestive tract, is not only responsible for digestion and absorption of dietary nutrients, but also plays a key role in immune homeostasis, protecting the body from various dietary allergens, antigens, toxins, and pathogens

10.1016/j.msec.2019.03.095 4 AlaviM.NokhodchiA

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[4] Von Schlippe M, Fowler CJ, Harland SJ