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Riboflavin also plays a role in thyroxine metabolism, and its deficiency may contribute to mental illness, because riboflavin activates vitamin B6, leading to lower thyroxine levels, reduced hypothalamic serotonin synthesis, and decreased levels of S-adenosylmethionine (SAMe), because of disrupting the folate-methylation pathways involved in SAMe synthesis, all of which are associated with antidepressant effects, consequently, low levels of these compounds may cause depression ( Figure 4 ) (48, 49)

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1.4 Fungal sepsis Even though fungi are a component of the normal flora in numerous body regions (in the gut, on the skin, in the mouth, and other mucosal surfaces), fungal sepsis exhibits a rapid growth rate and is frequently fatal in nature, exhibiting a mortality range of 40% to 60% among patients with invasive candidiasis or candidemia (Upperman et al., 2003

Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity

N-Acetylcysteine (NAC) Co-Supplementation NAC is the rate-limiting precursor for endogenous glutathione synthesis

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