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doi: 10.1007/s00239-021-10021-5

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17 Immune response modulation: Estrogen interacts with estrogen receptor-beta (ER-), which regulates key components of the innate immune response, such as the inflammasome

[DOI] [PubMed] [Google Scholar] 31.Priyadarsini K.I., Maity D.K., Naik G.H., Kumar M.S., Unnikrishnan M.K., Satav J.G., Mohan H

Methods: Plasma samples were collected from a phase 1b, open-label trial (NCT05117489) of adult pts with MASH who received MIRI 30200 mg intermittently or daily for 12 or 24 wks

When STING pathway is stimulated, IFNs and pro-inflammatory cytokines are produced via downstream IRF3 and NF-kB pathways to inhibit hepatitis virus replication, initiate the immune response, facilitate the oncogenesis and metastasis of HCC (122)