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Biotransformation of some drugs are affected by acetylation rates, examples include hydralazine (Apresoline) and isoniazid (INH).: Pharmacogenetics: One major concern is that on underlying disease state may not be appreciated until an unexpected reaction to an anesthetic agent in fact occurs

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However, poor nutrition, environmental toxins, chronic stress, and aging can reduce glutathione levels

In humans, the role of G6PD deficiency and hemolysis has been well documented, and the antioxidant nature of G6PD has underscored its protective effects against the development of a variety of other pathologies, including diabetes and CVD