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Notably, patients with insulin-secreting tumors experience a smaller increase in -hydroxybutyrate due to the inhibitory effects of insulin on ketogenesis and lipolysis [76]

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Neuroreport 19 , 277281 (2008)

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66 This phenomenon observed in preclinical studies along with other positive outcomes during the phase I trial have allowed BI836845 to continue to clinical trial phase II, where it is used in combination with an mTOR inhibitor (everolimus) and an aromatase inhibitor (exemestane) in metastatic breast cancer patients (NCT02123823)

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