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The data of gene expression profiling have been uploaded to the NCBI Gene Expression Omnibus under accession number GSE152537

However, the reduction in contractility observed in the presence of tempol in the AG (44% reduction, compared to the absence) may be due to the conversion of O 2 into H 2 O 2 stimulated by this mimetic, thereby reducing the amount of O 2 and its availability for ONOO formation, which is produced through its reaction with NO , ultimately decreasing tracheal hyperresponsiveness

It is currently being investigated in phase 3 trials, and results from a phase 2 trial published in the New England Journal of Medicine are show great promise

However, excess ROS induces inflammatory cell infiltration and macrophage polarization through mitochondrial homeostasis disruption and production of pro-inflammatory factors, forming a vicious cycle of central nerve inflammation and ROS production, further aggravating inflammation and the formation of glial cell scar