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Instead, only HTTex-145Q was able to induce an increase in the number of EGFP-TFE3 inclusions, even if the size of these inclusions remained unchanged (Fig

I., Visconti, K

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Its sequence contains two cysteine residues that form a disulfide bridge, giving the fragment a constrained loop structure important for its activity

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In genetic forms of PD, mutations in genes such as PINK1 , PARKIN , DJ-1 , and LRRK2 further highlight the vulnerability of mitochondrial and proteostatic systems, offering potential therapeutic targets [7, 13, 14]