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Role of glutathione S-transferases in the spinocerebellar ataxia type 2 clinical phenotype

Additionally, the intracellular GSH was not changed at 12 hours between control and CSE but by 24 and 48 hours there was significantly increased intracellular GSH in the CSE exposed cells (Figure 1B)

The protocols in our animal studies were approved by the Institutional Animal Care and Use Committee of Chang Gung University

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As such, the formation of the hydroquinoneGSH conjugate cannot be considered as a detoxification mechanism itself, causing the resulting adducts to be nephrotoxic and myelotoxic