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618 In 2019, LNPs formulated with 306-O12B-3/cholesterol/DOPE/DSPE-PEG2000 at a ratio of 16:4:1:1 (w/w) were used to deliver ASOs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) in mice, resulting in significant PCSK9 silencing with the ED 50 as low as 0.034 mg/kg following systemic administration

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In these contexts, iron chelation may fail to address the upstream drivers of cell death and may even activate alternative death pathways

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