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T cell-specific DUSP8 cKO mice are resistant to ovalbumin-induced asthma, whereas the symptoms are restored by Pur- heterozygous cKO

In the latest clinical trial, OS and progression-free survival (PFS) in months was calculated for Phase 2 of Tepotinib 500 mg (5.55 and 3.22 months, respectively) (NCT02115373)

FDA found no data supporting effectiveness through the nominated subcutaneous route

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Human physiology is governed by interconnected systems, feedback loops, adaptation, and variability

Beyond nausea, the gastrointestinal side effect cluster includes diarrhea, vomiting, constipation, and decreased appetite, which is technically a desired effect but can become problematic at extreme levels