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With a stoichiometric network, based on the law of mass action and thermodynamics, model was able to indicate the key altered metabolic reprogramming states in the presence of CBZ in core metabolism ( photosynthesis, pentose phosphate pathway, folate metabolism, biomass precursors synthesis ), synthesis of precursors of secondary metabolites (chorismate, terpenoid) and nutrient assimilation reported in CBZ exposure in plants

(2015) 47:e274

To overcome this technical issue, sequences that caused abnormal branch lengths in the tree were removed (Additional file 1: Table S5), and the dataset was subdivided into smaller datasets representative of all SVCT genes here found (SVCT1 , SVCT2 , SVCT3 , SVCT4 and SVCT5 ), as well as four subsets, representative of non-bilaterians ( SVCTNB ), protostomian Lophotrochozoa ( SVCTP L ), protostomian Non-Lophotrochozoa ( SVCTP NL ) and basal deuterostomians ( SVCT BD )

Finally, clemastine was reported to improve electrophysiological changes and promote peripheral myelin repair in a murine model of compression neuropathy (Lee et al., 2021)

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