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H2RAs impede the interaction between histamine and gastric parietal cells, whose role is to stimulate the H+/K+ ATPase pump [45]

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ROS-induced HIF-1 stabilisation leads to the activation of macrophages in the early stages of wound healing, and promotes metabolic reprogramming towards glycolysis 75,76 , as well as increased angiogenesis 76

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Subsequent developments in ionization techniques like electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI), along with enhancements in chromatographic separation technologies such as ultra-high performance liquid chromatography (UPLC) and high-performance liquid chromatography (HPLC), propelled chromatography-mass spectrometry coupling towards higher throughput and greater versatility