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Disease-causing LRRK2 variants are characterised by a gain of kinase function including phosphorylation of Ras-associated binding (Rab) proteins

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Nat Rev Neurosci

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This can include: Air pollution (car exhaust, industrial pollutants, poor indoor air quality) Household cleaning products (sprays, disinfectants, synthetic fragrances) Personal care products (lotions, shampoos, perfumes with added chemicals) Pesticides and herbicides on non-organic foods Plastics (water bottles, food storage containers, packaging) Heavy metals (from water, old pipes, certain fish, or past exposures) Were not trying to eliminate everything, thats not realistic

Profaci CP, Munji RN, Pulido RS, Daneman R