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However, large-scale randomized controlled trials in humans remain absent from Western medical literature

Treatment of Glaucoma with natural products and their mechanism of action: an update

Vasconcelos AR1

A large trial reported in 1994 (pdf) that daily megadoses of the antioxidant beta-carotene increased the risk of lung cancer in male smokers by 18 percent and a 1996 trial was stopped early after researchers discovered that high-dose beta-carotene and retinol, another form of vitamin A, increased lung cancer risk by 28 percent in smokers and workers exposed to asbestos

Chatfield MJ, La Mar GN

Patients should ask three questions before considering any stack: What specific problem is each treatment intended to address