l glutathione and lung cancer inhibits development by reducing interleukin-6 expression reversing the Warburg effect Regulation of antioxidants in cancer:

Table 2 Criteria for delineation of the study, using the PICOS strategy

PMID: 35780904 Cell Tissue Res2022 Oct;390(1):93-112

1, 2 More than 120 years had indeed to pass from Peyrones observations for the American chemist Barnett Rosenberg to characterize the robust antiproliferative effects of CDDP, first in Escherichia coli cultures, then in solid and hematopoietic tumor xenografts

It directly targets malic enzyme 1 (ME1) and inhibits cell proliferation via downregulation of NADPH production and fatty acid synthesis, thereby affecting KRAS-mutant-driven CRC progression [155]

Although miRNAs are primarily known for repressing translation, some of them can also activate gene expression under certain conditions

The acquired resistance mechanism of covalent KRAS (G12C) inhibitors Despite acquiring promising preliminary clinical results from KRAS (G12C) inhibitors, it should be cautioned that complete responses are rare in clinical trials 225,226