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Free Radical Biology & Medicine, 44 , 17871794

Serum was obtained from freshly drawn blood after an overnight hold at 4C and all samples were then deidentified

10.1016/j.immuni.2012.08.027 55

10.1097/BRS.0b013e3181d74414 48 NestiL

FIGURE 2 Regulation of Nrf2 Activity Keap1-Dependent Regulation of Nrf2 Activity Keap1 is a cysteine rich adaptor protein for cullin (Cul3)-containing E3 ubiquitin ligase complex which mediates Nrf2 ubiquitination and degradation by 26S proteasomes