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It overrides your pituitary and supplies exogenous GH

Fasting glucose matters because GH can affect insulin sensitivity transiently, and a patient with undiagnosed prediabetes needs a different conversation before starting a GH secretagogue than a metabolically healthy patient does

Ghrelin and Control of Energy Balance Control of energy balance through two types of neurons of the arcuate nuclei: (1) Proopiomelanocortin (POMC) neurons that release amelanocyte- stimulating hormone (-MSH) and Cocaineand Amphetamine Regulated Transcript (CART), reducing food intake and increasing energy expenditure

Instead it potentiated them, suggesting that the putative U factor complemented the GH-releasing effects of GHRH and GHS

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