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This effect is not only assigned to the GSH layer, but also to the presence of extra hydrate layers in aqueous medium

10.1007/s004380050840 Mol

However, a potent and subtype-selective PPARdelta agonist called GW501516 has been developed using combinatorial chemistry and structure-based drug design

Indeed, a recent review explicitly notes that bacteria exposed to plant-derived phytochemicalsincluding OSCsmay evolve resistance through general stress-response mechanisms such as efflux pump upregulation, enzymatic detoxification, or metabolic remodeling under sublethal exposures (Vaou et al., 2021)

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hormaechei strain was comparable to 2,4-D tested at the same concentrations