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Treatment strategies with epigenetic enzymes, primarily targeting histone modifiers (such as histone deacetylase, 520 histone demethylase 521 and histone methyltransferase, 522 ) show therapeutic potential in animal models

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Comorbidities present in pillar pain patients included hypertension (48%), hypothyroidism (30%), rheumatoid arthritis (26%), diabetes mellitus (22%), fibromyalgia (9%), and vitamin deficiencies (9%), with no cases of chronic kidney disease in this sample