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If the response to an opioid overdose reversal agent is suboptimal or only brief in nature, administer additional antagonist as directed by the products prescribing information

10.1002/adhm.202300530 144 ZhangJ.ChangL.HaoR.ZhangG.LiuT.LiZ.et al (2023)

FDA-NIH biomarker working group, BEST (Biomarkers, EndpointS, and other Tools) resource, Silver Spring (MD): Food and Drug Administration

Abstract The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be