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For example, in the 1-2 days after the injection, I get very fatigued and nauseous

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Since high levels of GSTs are expressed in the hepatocytes and it has previously been demonstrated that GSTs display sulfonamidase activity, three sulfonamide prodrugs of metformin were designed and synthesized 120

doi: 10.1038/nm.4106 236 ReyndersTDevolderLValles-ColomerMVan RemoortelAJoossensMDe KeyserJet al