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Antiviral defense mechanisms in honey bees

Prominent ketosteroid isomerase activity is displayed by HsaGST A3-3, and approximately 10-fold lower by HsaGST A1-1, but not by the other alpha class GSTs ( Discovery of Ketosteroid Isomerase In 1955 Talalay and Wang discovered a new enzymatic reaction involving ketosteroids, including 5-androsten-3,17-dione (5-AD) and 5-pregnen-3,20-dione (5-PD), and purified a highly active isomerase from Pseudomonas bacteria (Talalay and Wang, 1955)