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While improvement in clinical pregnancy rates have been shown in some studies, so far improvement in live birth and miscarriage rates have not been established

In another approach, PC was activated by bovine thrombin immobilized on Sepharose 4B beads 14 , however in all above mentioned approaches, the yield of separation and the specific activity of APC remain unknown

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However, continued activation of p53 triggers a pro-oxidation reaction that induces cell death