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TB-500 provides critical enhancement of cellular migration and epithelial coverage that drives wound closure, with research demonstrating that topical or intraperitoneal TB-500 administration increases reepithelialization by 42% over controls at 4 days post-wounding and 61% at 7 days, with treated wounds showing enhanced contraction (at least 11% more than controls by day 7) and superior architectural organization

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Liposomal delivery systems encapsulate AHK-Cu in lipid spheres, potentially improving penetration through the stratum corneum and protecting the peptide from degradation

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This phenomenon is commonly referred to as pressure natriuresis